| Position | Official |
| WHITE HOUSE/EXECUTIVE OFFICE OF THE PRESIDENT | |
| Assistant to the President for National Security Affairs/National Security Advisor, National Security Council (NSC) | John Bolton |
| Senior Director for Global Health Security and Biothreats, NSC | Tim Ziemer |
| Director for Countering Biological Threats, NSC | Hillary Carter |
| Director for Global Health and International Development, NSC | Peter Mamacos |
| Director, Office of Management and Budget (OMB) | Mick Mulvaney |
| Associate Director for National Security Programs, OMB | Robert Blair |
| Deputy Associate Director, International Affairs Division, National Security Programs, OMB | Robert Fairweather |
| Chief, Economic Affairs Branch, International Affairs Division, National Security Programs, OMB | Fouad Saad |
| Program Examiner, International Affairs Division, National Security Programs, OMB | Will Cole |
| Associate Director, Health Programs, OMB | Joe Grogan |
| Deputy Associate Director, Health Division, Health Programs, OMB | Tom Reilly |
| Chief, Public Health Branch, Health Programs, OMB | Marc Garufi |
| Program Examiner, Public Health Branch, Health Programs, OMB | Nicholas Burton |
| U.S. Trade Representative, Office of the United States Trade Representative (USTR) | Robert Lighthizer |
| Deputy U.S. Trade Representative, USTR | C.J. Mahoney |
| Assistant U.S. Trade Representative, Innovation and Intellectual Property, USTR | Vacant |
| Associate Director for National Security and International Affairs, National Security and International Affairs Division, Office of Science and Technology Policy (OSTP) | Vacant |